Actively Recruiting
Percept Transitions in FOG and PD
Led by University of Minnesota · Updated on 2026-03-03
36
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
Sponsors
U
University of Minnesota
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease, with and without freezing of gait (FOG). This will be conducted as three separate experiments, participants may volunteer for one or more experiments: Experiment 1: The first experiment will compare LFPs during gait initiation with and without a cue, in people with (PD+FOG) and without FOG (PD-FOG). Experiment 2: The second experiment will compare LFPs during the successful movement transitions vs. freezing-events during a FOG provocation course in people with FOG. Experiment 3: The third experiment will compare LFPs during rapid alternating movements of the wrist and/or foot, in people with and without FOG
CONDITIONS
Official Title
Percept Transitions in FOG and PD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of idiopathic PD.
- Age 21-75 years.
- Able to walk independently without an assistive device for 50 meters.
- Implanted Medtronic Percept TM device.
- At least 3 months since neurostimulator activation.
- Inclusion allowed for undervalued, under-represented, or disenfranchised social groups.
- Active military members and DoD personnel may participate.
- Inclusion allowed for socially disadvantaged individuals regarding income, housing, or healthcare.
You will not qualify if you...
- Diagnosis of dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, or other neurodegenerative disorders.
- History of seizures or significant neurological disorders affecting study participation.
- History of musculoskeletal disorders significantly affecting walking or limb movement (may limit participation to some tasks).
- History of muscular conditions of neck and back, including whiplash, affecting walking experiments.
- History of visual or vestibular conditions affecting study participation.
- Reduced capacity to consent as assessed by specific tests.
- Pregnant individuals.
- Post-operative complications or adverse effects affecting safety or study results.
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota, Movement Disorders Lab
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
M
Madison Aasen, MS
CONTACT
S
Sommer Amundsen-Huffmaster, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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