Actively Recruiting

Age: 13Years - 65Years
All Genders
Healthy Volunteers
NCT03407066

Perception, Sensation, Cognition and Action in Humans

Led by National Eye Institute (NEI) · Updated on 2026-05-01

10200

Participants Needed

2

Research Sites

457 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Background: When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happens. Researchers want to explore how healthy brains process sights and sounds. Objectives: To explore how people understand what they see and hear when the brain processes sights and sounds. Eligibility: Participants aged 13-65 who have at least 20/40 vision in at least one eye and do not use a hearing aid. Design: Some participants will take tests online anonymously. They will do computer tasks related to colors and behavior. In-person participants will be screened with medical history and physical exam. They will complete questionnaires and vision and hearing tests. Participants will plan how many testing sessions they will have and when. Sessions last 2-5 hours. They may include: * Magnetic Resonance Imaging: Magnets and radio waves to take pictures of the brain. Participants will lie on a table that slides in and out of a tube. They will do a task during the scan. * Magnetoencephalography: Records magnetic field changes from brain activity. Participants will sit or lie down. A cone will be lowered onto their head. They may do a task during the test. * Electromyography: Electrodes attached to the skin will measure the electrical activity of muscles. * Electroencephalogram: Electrodes on the scalp will record brain waves. * Electrocardiography: Electrodes on the chest will record heart electrical activity. * Tests of memory, attention, thinking, vision, and hearing. * Eye Tracking: Cameras will follow participants eye movements. They may wear a cap with infrared cameras in front of their eyes. During the sessions, participants vital signs may be monitored.

CONDITIONS

Official Title

Perception, Sensation, Cognition and Action in Humans

Who Can Participate

Age: 13Years - 65Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Be between 18 and 65 years old for in-lab or online participation, or between 13 and 65 years old for off-site participation
  • Be in good general health
  • Have visual acuity of 20/40 or better in at least one eye (corrected with contact lenses is acceptable)
  • Have no hearing impairment requiring a hearing aid (for in-lab participants)
  • Be capable of understanding the study procedures and requirements
  • Be willing and able to provide informed consent
Not Eligible

You will not qualify if you...

  • Pregnancy
  • Serious vision or hearing problems; colorblindness excludes some sub-studies focused on normal color vision
  • Lack of consent capacity
  • Debilitating neurological disorders (e.g., brain tumor, epilepsy, Alzheimer's, Parkinson's, multiple sclerosis) or psychiatric disorders (e.g., schizophrenia, severe depression, ADHD)
  • Serious head injury with loss of consciousness for 30 minutes or more or history of brain surgery
  • Psychoactive drug or alcohol abuse or dependence in the past three months (except nicotine and caffeine)
  • Employment with the Perception, Cognition and Action section at NEI
  • Contraindications to MRI including metal implants, claustrophobia, inability to lie still, weight over 450 lbs, certain medical devices or conditions
  • Use of nicotine or caffeine within two hours prior to MRI sessions
  • For online participants: lack of compatible equipment, unwillingness to allow JavaScript or agree to online platform terms and conditions

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

National Eye Institute (NEI)

Bethesda, Maryland, United States, 20892

Actively Recruiting

2

National Institutes of Health Clinical Center

Bethesda, Maryland, United States, 20892

Actively Recruiting

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Research Team

M

Marianne F Duyck, Ph.D.

CONTACT

B

Bevil R Conway, Ph.D.

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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