Actively Recruiting
Percutaneous Blockade of the Stellate Ganglion in Electrical Storm
Led by University of Sao Paulo General Hospital · Updated on 2025-10-07
64
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is no randomized clinical study in the literature that evaluated the efficacy and safety of the stellate ganglion infiltration procedure in patients with electrical storm. So far, case reports and retrospective studies suggest that such a strategy should be considered in cases refractory to initial therapy. In this scenario, the European and American guidelines for the treatment of ventricular arrhythmias recommend autonomic modulation in this setting, but only with a level of recommendation IIb (1,2). This project aims to evaluate the effect of stellate ganglion infiltration in patients with electric storm refractory to initial clinical measures. It is a randomized clinical trial where patients will receive treatment with a lidocaine and bupivacaine anesthetic solution or no intervention. The effect of the intervention will be considered positive when there is a reduction of arrhythmic events of at least 50% in the 12 hours immediately after.
CONDITIONS
Official Title
Percutaneous Blockade of the Stellate Ganglion in Electrical Storm
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old with structural heart disease and refractory electrical storm
- Patients who require stopping antiarrhythmic drugs due to side effects or contraindications to standard therapy
You will not qualify if you...
- Patients under 18 years old
- History of heart transplant or prior cardiac denervation surgery
- Anatomical contraindications for the procedure such as prior neck surgery, burns, large scars, or thyroid goiter
- Genetically related polymorphic ventricular tachycardia
- End-stage renal disease requiring dialysis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Clinical Research Center of the Heart Institute - University of São Paulo
São Paulo, São Paulo, Brazil, 05409011
Actively Recruiting
Research Team
A
Alberto P Ferraz, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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