Earlier preoperative percutaneous intercostal cryoanalgesia improves recovery after pectus excavatum surgery.
Stefano Mariconti, Alfio Bronco, Isabella Pellicioli...
https://pubmed.ncbi.nlm.nih.gov/39510802/Actively Recruiting
Led by Papa Giovanni XXIII Hospital · Updated on 2025-07-23
20
Participants Needed
1
Research Sites
8 weeks
Total Duration
Researchers are investigating the timing of pain relief onset from percutaneous intercostal cryoneurolysis in patients undergoing the Nuss procedure for pectus excavatum. This observational study focuses on evaluating how soon the cryoneurolysis technique affects chest skin sensitivity to various stimuli after the procedure. The main goal is to understand when cryoanalgesia begins to take effect to better manage postoperative pain. Participants receive preoperative percutaneous intercostal cryoneurolysis as part of their treatment for pectus excavatum correction. The study involves physical examinations assessing chest skin sensitivity to soft touch, cold water at 4C, and warm water at 40C over the days following the cryoneurolysis procedure. This approach helps track changes in sensory responses after the intervention. During the study, participants undergo repeated physical assessments focused on thermal and touch sensitivity of the chest skin. Researchers measure changes in thermal sensitivity as the primary outcome and chest skin sensitivity to touch as a secondary outcome, with evaluations occurring over approximately one week. The study includes participants aged 12 to 40 years and allows healthy volunteers who meet the criteria to join. The total time commitment and follow-up are aligned with the postoperative monitoring period.
CONDITIONS
Percutaneous Intercostal Cryoneuromodulation Onset Timing.
S
Stefano Mariconti, MD
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Papa Giovanni XXIII Hospital
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 week
Participants who undergo preoperative percutaneous intercostal cryoneurolysis are observed and assessed through physical examinations of chest skin sensitivity.
1 to 2 visits depending on assessments
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Stefano Mariconti, Alfio Bronco, Isabella Pellicioli...
https://pubmed.ncbi.nlm.nih.gov/39510802/Papa Giovanni XXIII Hospital
Lead Sponsor