Genicular Artery Embolization for the Treatment of Symptomatic Knee Osteoarthritis.
Florian N Fleckenstein, Tazio Maleitzke, Timo A Auer...
https://pubmed.ncbi.nlm.nih.gov/40693933Actively Recruiting
Phase Not Applicable
Age: 40Years - 80Years
All Genders
ID07361198
Percutaneous Transcatheter Genicular Embolization in Osteoarthritis
Led by Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s. · Updated on 2026-02-04
20
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating a minimally invasive procedure called percutaneous transcatheter embolization of knee arteries to treat patients with chronic knee pain caused by advanced knee osteoarthritis or ongoing pain after total knee replacement. This study aims to assess whether blocking small arteries supplying inflamed knee tissues can reduce abnormal blood flow linked to inflammation, potentially relieving pain and improving knee function. The study focuses on safety and effectiveness over a follow-up period of up to 24 months. The procedure involves guiding a thin catheter through the blood vessels to the knee under local anesthesia in an angiography suite. Using imaging techniques, doctors identify abnormal blood vessels showing increased blood flow and apply a temporary embolic suspension to reduce flow in these targeted vessels while preserving normal circulation. Participants undergo clinical and imaging assessments before the procedure and at scheduled follow-ups throughout the two-year study. During the study, participants complete evaluations of pain intensity and knee function using standard scales at 1, 3, 6, 12, and 24 months after the procedure. Researchers monitor for any side effects or complications related to the treatment and collect data on medication use. The study emphasizes patient safety, technical feasibility, and tracking changes in quality of life and knee condition over time to provide insights for future research and potential treatment options.
CONDITIONS
Brief Title
Percutaneous Transcatheter Genicular Embolization in Osteoarthritis
Who Can Participate
Age: 40Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 40 to 80 years
- Chronic knee pain consistent with clinical symptoms
- Radiographic confirmation of knee osteoarthritis (Kellgren-Lawrence grade II-IV) or persistent knee pain after total knee replacement
- Insufficient pain relief from standard conservative treatments such as medications, physical therapy, or injections
- Ability to understand study procedures and provide written informed consent
- Willingness and ability to follow study procedures and attend follow-up visits
You will not qualify if you...
- Active local or systemic infection
- Known bleeding or coagulation disorders or anticoagulation therapy that cannot be safely stopped
- Significant peripheral arterial disease in the lower limbs
- Allergy or contraindication to iodinated contrast agents
- Severe kidney impairment
- History of fibromyalgia or other chronic generalized pain conditions
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 1 day
Participants undergo a catheter-based genicular artery embolization procedure performed under local anesthesia to target abnormal blood vessels associated with knee osteoarthritis.
1 procedure visit (in-person)
Follow-up
Duration - 2 years
Participants attend scheduled follow-up visits over two years to assess clinical status and monitor for any procedure-related adverse events.
5 visits at 1, 3, 6, 12, and 24 months after the procedure (in-person)
Trial Site Locations
Total: 1 location
1
Masarykova nemocnice v Ústí nad Labem
Ústí nad Labem, Czechia, 40011
Actively Recruiting
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Research Team
P
Patrik Matras, MUDr.
P
Pavol Viglas
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Published Research Related To This Trial
Multicenter Randomized Sham Controlled Study of Genicular Artery Embolization for Knee Pain Secondary to Osteoarthritis.
Sandeep Bagla, Rachel Piechowiak, Abin Sajan...
https://pubmed.ncbi.nlm.nih.gov/34610422Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis.
Yuji Okuno, Amine Mohamed Korchi, Takuma Shinjo...
https://pubmed.ncbi.nlm.nih.gov/24993956Genicular artery embolisation versus sham embolisation for symptomatic osteoarthritis of the knee: a randomised controlled trial.
Tijmen A van Zadelhoff, P Koen Bos, Adriaan Moelker...
https://pubmed.ncbi.nlm.nih.gov/39353688