Actively Recruiting
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke
Led by University Hospital, Basel, Switzerland · Updated on 2026-03-09
1000
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A large, worldwide study called PREVENT is looking at a complication that can happen during a stroke treatment called thrombectomy. This complication is a perforation of a blood vessel. The investigators aim to: 1. Find what factors make this perforation more likely. 2. Understand why the perforation happens by looking closely at images taken during the procedure. 3. Create a simple way to classify these perforations to help doctors decide how to treat them right away. 4. Improve the emergent treatment of vessel perforation to stop the bleeding rapidly. 5. Provide data to guide decision whether thrombectomy should be continued or aborted after the event of vessel perforation. 6. Develop a safer way to perform thrombectomy. Investigators will compare the results collected for patients where perforation happened with those where perforation did not happen.
CONDITIONS
Official Title
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at time of thrombectomy
- Acute ischemic stroke with occlusion of one or more intracranial arteries treated by thrombectomy
- For the target group: occurrence of intracranial vessel perforation during thrombectomy with contrast leakage seen on angiography
- For the comparison group: no perforation during thrombectomy, matched by age, gender, center, and occlusion location to target group patients
You will not qualify if you...
- Documented rejection of participation
- Presence of both ischemic stroke and intracranial hemorrhage on imaging before treatment
- Intracranial dissection without active contrast leakage
- Rupture of a pre-existing intracranial aneurysm during thrombectomy
- Contrast leakage into venous spaces such as the cavernous sinus leading to carotid-cavernous fistula
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
V
Victor Schulze-Zachau, MD
CONTACT
M
Marios N Psychogios, Prof. Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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