Actively Recruiting
Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules
Led by University Hospital, Bordeaux · Updated on 2025-02-19
50
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lung cancer screening trials using low-dose chest CT scans have shown a significant reduction of cancer related mortality in subjects at high risk of lung cancer. However, high rate of false positives and overdiagnosis have led to invasive methods, which are not without risks. Evaluation of lung nodules using lung MRI with ultra short echo time sequences (UTE) has been found comparable to chest CT scans. Moreover, MRI has the advantage of multiparametric characterization of lesions using different tissue contrasts. Following the recommendation of the French National Authority for Health (HAS) to evaluate new methods of lung cancer screening, this prospective single center pilot study is designed to evaluate the performance of multiparametric lung MRI combined to synthetic CT in the diagnosis of lung cancer in heavily smokers or ex-smokers professionally exposed to carcinogens
CONDITIONS
Official Title
Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject aged between 55 and 74 years
- High risk of developing lung cancer due to exposure to lung carcinogens and smoking (30 pack-years or cessation less than 15 years)
- Presence of at least one solid lung nodule 5 mm or larger on the initial scan
- Ability and willingness to complete all scheduled visits and assessments
- Subject has health insurance
- Signed informed consent
You will not qualify if you...
- Signs of lung cancer
- History of lung cancer
- Severe life-threatening comorbidities within 6 months (recent stroke or advanced cancer discovery)
- Chest scan performed less than one year ago
- No exposure to occupational lung carcinogens as defined
- No or insufficient tobacco exposure or cessation more than 15 years ago
- Contraindications to MRI (pacemaker, implants, claustrophobia)
- Pregnant or breastfeeding women
- Poor understanding of French
- Subject under legal protection
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU Bordeaux
Pessac, France
Actively Recruiting
Research Team
I
Ilyes Benlala, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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