Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas.
Meng-Si Liu, Zhao-Yang Tian, Zhou Zhang...
https://pubmed.ncbi.nlm.nih.gov/36263685/Actively Recruiting
Age: 20Years - 65Years
All Genders
Healthy Volunteers
ID05357456
Study Comparing Brain and Cognitive Functions in Patients With Autonomous Cortisol Secretion and Non-functioning Adrenal Adenomas Impact of Different Treatments on Brain and Cognitive Health in Autonomous Cortisol Secretion Patients
Led by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Updated on 2022-05-02
62
Participants Needed
1
Research Sites
104 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are conducting a single-center, prospective, observational study to explore how cognitive function and brain function differ between patients with autonomous cortisol secretion ACS and those with non-functioning adrenal adenomas. The study also evaluates how different treatments affect cognitive and brain function in patients with ACS. This research addresses a gap in understanding the impact of ACS on cognition and brain activity, using functional MRI as an important tool. Patients admitted with adrenal incidentalomas undergo evaluation for adrenal function to determine whether they have ACS or non-functioning adrenal adenomas based on serum cortisol levels after a dexamethasone suppression test. Those diagnosed with ACS will receive either laparoscopic adrenal surgery or conservative treatment. Both ACS patients and those with non-functioning adrenal adenomas will have physical exams, cognitive function tests, and brain MRI scans. ACS patients will be assessed at baseline and again 12 months after their treatment, while non-functioning adenoma patients will be assessed at baseline only. Participants will undergo multiple assessments including cognitive tests like the Montreal Cognitive Assessment MoCA, Mini-Mental State Examination MMSE, and Repeatable Battery for the Assessment of Neuropsychological Status RBANS. Brain function will be evaluated via resting functional MRI. Researchers will collect personal and physical data, screen adrenal cortisol secretion, and monitor changes in cognitive function and brain imaging over 12 months after treatment for ACS patients. The study aims to understand cognitive and brain changes related to ACS and the effects of treatment over time.
CONDITIONS
Brief Title
Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
Research Team
D
Dalong Zhu, MD,PhD
P
PIng Li, MD,PhD
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