Actively Recruiting
Peri-implantitis Management: Surgical and Maintenance Outcomes
Led by University of Pittsburgh · Updated on 2026-05-01
44
Participants Needed
1
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how two standard surgical treatments for peri-implantitis affect inflammation around dental implants. Participants will be randomly assigned to receive resective surgery with implantoplasty or resective surgery with mechanical debridement only. Participants will provide blood samples before surgery, about 48 hours and 2 weeks after surgery. Participants will also provide a small gum tissue sample and fluid from around the implant at baseline and about 3 months after surgery. Participants will be followed in a maintenance program for up to 5 years.
CONDITIONS
Official Title
Peri-implantitis Management: Surgical and Maintenance Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 or older
- In good general health, classified as ASA Physical Status I or II
- Diagnosed with peri-implantitis requiring resective surgical treatment, defined by bleeding on probing around implants
- Probing pocket depths greater than 6 mm
- Implants in function for over 1 year with progressive bone loss exceeding 3 mm
- Initial diagnosis confirmed by panoramic radiographs, cone-beam CT, and clinical exam
- For maintenance phase: probing depth of 5 mm or less
- Bleeding on probing at 1 point or less
- No suppuration present
- No progressive bone loss compared to pre-treatment levels
You will not qualify if you...
- Autoimmune or systemic inflammatory diseases like lupus or rheumatoid arthritis
- Chronic use of systemic corticosteroids or immunosuppressants in the past 3 months
- Uncontrolled diabetes with HbA1c greater than 7.5%
- Active infection or antibiotic use within 30 days before baseline
- Pregnancy or breastfeeding
- Unable to undergo venipuncture or tolerate soft tissue biopsy
- Unable to attend 3-month follow-up or comply with study protocol
- History of cancer requiring systemic therapy within past 5 years
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Pittsburgh School of Dental Medicine
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
A
Andrea Ravida, DDS, MS, PhD
CONTACT
C
Carla Sanchez, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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