Actively Recruiting
Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty
Led by University of California, San Francisco · Updated on 2025-10-24
60
Participants Needed
2
Research Sites
210 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
M
MedStar Georgetown University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial. Hypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.
CONDITIONS
Official Title
Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men, age 18 or older
- Undergoing anterior urethroplasty with buccal grafting
- Able to consent
You will not qualify if you...
- Taking chronic opiates for pain
- Diagnosis of chronic pain
- Prior buccal urethroplasty
- Vulnerable population (e.g. prisoner)
- Renal dysfunction or allergy preventing NSAID use
- Liver dysfunction or allergy preventing Tylenol use
- Medical allergy to local anesthetic
- Medical allergy to Peridex/Magic Mouthwash
- NYHA Class III/IV heart failure
- Hematologic condition that excludes patient from surgery
- Post-operative complication resulting in inpatient stay
- Anesthetic complication
- No buccal site surgical complication
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
2
MedStar Urology
Washington D.C., District of Columbia, United States, 20037
Actively Recruiting
Research Team
L
Lindsay A Hampson, MD
CONTACT
S
Sara Z Amare, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here