Actively Recruiting

Phase 3
Age: 18Years +
MALE
NCT05300685

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

Led by University of California, San Francisco · Updated on 2025-10-24

60

Participants Needed

2

Research Sites

210 weeks

Total Duration

On this page

Sponsors

U

University of California, San Francisco

Lead Sponsor

M

MedStar Georgetown University Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial. Hypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.

CONDITIONS

Official Title

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

Who Can Participate

Age: 18Years +
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Men, age 18 or older
  • Undergoing anterior urethroplasty with buccal grafting
  • Able to consent
Not Eligible

You will not qualify if you...

  • Taking chronic opiates for pain
  • Diagnosis of chronic pain
  • Prior buccal urethroplasty
  • Vulnerable population (e.g. prisoner)
  • Renal dysfunction or allergy preventing NSAID use
  • Liver dysfunction or allergy preventing Tylenol use
  • Medical allergy to local anesthetic
  • Medical allergy to Peridex/Magic Mouthwash
  • NYHA Class III/IV heart failure
  • Hematologic condition that excludes patient from surgery
  • Post-operative complication resulting in inpatient stay
  • Anesthetic complication
  • No buccal site surgical complication

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 2 locations

1

University of California San Francisco

San Francisco, California, United States, 94143

Actively Recruiting

2

MedStar Urology

Washington D.C., District of Columbia, United States, 20037

Actively Recruiting

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Research Team

L

Lindsay A Hampson, MD

CONTACT

S

Sara Z Amare, BS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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