Actively Recruiting

Phase Not Applicable
Age: 16Years - 50Years
All Genders
ID03481010

Periacetabular Osteotomy With and Without Arthroscopic Treatment of Hip Joint Abnormalities: A Multicenter Randomized Controlled Trial

Led by Ottawa Hospital Research Institute · Updated on 2025-12-30

204

Participants Needed

7

Research Sites

21 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying hip dysplasia, a condition where the hip socket develops abnormally causing joint stress and early arthritis. This trial aims to find out if adding a hip arthroscopy procedure to a periacetabular osteotomy (PAO) surgery improves patient outcomes compared to PAO alone. Patients with symptomatic acetabular dysplasia will be randomly assigned to receive either treatment and followed for two years to assess differences in symptoms and recovery. The study compares two groups: one receiving only the PAO surgery, which repositions the hip socket to reduce joint stress, and another receiving PAO combined with hip arthroscopy, a minimally invasive procedure to address additional joint abnormalities like labral tears. Both treatments are surgical, and the decision to operate is made by the patient and surgeon. The study will evaluate the added benefit of performing hip arthroscopy alongside PAO. Participants will undergo assessments before surgery and at 6, 12, and 24 months after surgery, including questionnaires measuring hip function and quality of life. Researchers will also track operative time, hospital stay length, adverse events, and cost-effectiveness. Follow-up visits will monitor recovery over two years, focusing on patient-reported outcomes and safety.

CONDITIONS

Brief Title

Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology

Who Can Participate

Age: 16Years - 50Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Skeletally mature patient undergoing Bernese periacetabular osteotomy for symptomatic acetabular dysplasia or hip instability
  • Pre-operative MRI at 3T and/or gadolinium MR arthrogram
  • Age between 16 and 50 years old
  • Patient capable of giving informed consent
Not Eligible

You will not qualify if you...

  • Prior hip or pelvis surgery on the surgical side
  • Prior hip arthroplasty surgery on either side
  • Radiographic evidence of arthritis (Tönnis grade =2)
  • Known connective tissue disorders (e.g., Ehlers-Danlos Syndrome)
  • Known neuromuscular disorders (e.g., Cerebral Palsy, Spina bifida)
  • Known skeletal dysplasia (e.g., Achondroplasia, Multiple Epiphyseal Dysplasia)
  • Cognitive impairment preventing accurate completion of patient-reported outcome questionnaires
  • Patient unable or unwilling to complete all required follow-up visits
  • Concurrent proximal femoral osteotomy and/or surgical hip dislocation surgery

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Up to 1 month

Participants undergo a periacetabular osteotomy (PAO) surgery, with some receiving an additional hip arthroscopy. This stage includes the surgery and the immediate recovery period in the hospital.

Hospital stay and follow-up visits during the first month post-surgery

Post-operative Follow-up

Duration - 24 months

Participants have scheduled visits to monitor recovery, assess symptoms, and evaluate outcomes after surgery.

Visits before surgery, and at 2-4 weeks, 3 months, 6 months, 12 months, and 24 months after surgery

Trial Site Locations

Total: 7 locations

1

Northwestern University

Chicago, Illinois, United States, 60611

Actively Recruiting

2

William Beaumont Hospital

Royal Oak, Michigan, United States, 48073

Actively Recruiting

3

The Washington University

St Louis, Missouri, United States, 63130

Actively Recruiting

4

Hospital for Special Surgery

New York, New York, United States, 10021

Actively Recruiting

5

Children's Hospital of Eastern Ontario

Ottawa, Ontario, Canada, K1H 8L1

Actively Recruiting

6

Ottawa Hospital Research Institute

Ottawa, Ontario, Canada, K1H8L6

Actively Recruiting

7

CHU de Québec - Université Laval

Québec, Canada, G1J 1Z4

Actively Recruiting

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Research Team

G

Geoffrey Wilkin, MD

C

Cheryl Kreviazuk

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Periacetabular osteotomy with or without arthroscopic management in patients with hip dysplasia: study protocol for a multicenter randomized controlled trial.

Geoffrey P Wilkin, Stéphane Poitras, John Clohisy...

https://pubmed.ncbi.nlm.nih.gov/32811527