Actively Recruiting
Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
Led by Virginia Commonwealth University · Updated on 2026-04-21
36
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.
CONDITIONS
Official Title
Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 12 to 21 years
- Able to communicate and provide consent or assent
- English speaking
- Diagnosed with POTS defined as a symptomatic heart rate rise of 40 bpm or more without blood pressure drop and with symptoms of orthostatic intolerance
- Age-matched healthy controls with no POTS or other neurological disorders
You will not qualify if you...
- Inflammatory arthritis, connective tissue, or autoimmune disorder
- Any chronic neurological disorder besides POTS
- Unstable medical disorders such as kidney or liver impairment, poorly controlled cardiovascular, respiratory, endocrine, or psychiatric illness
- Neuropathy or central nervous system disorders such as cerebral palsy, developmental delay, seizure disorder, multiple sclerosis, or stroke
- Treatment with unapproved drugs or medical devices within the last 30 days
- Use of hormones except insulin, thyroid replacement, or oral contraceptives
- Current substance or alcohol abuse
- Major surgery with general anesthesia in last 60 days or minor procedures with sedation in last 7 days
- Ongoing or pending medical, health, or disability-related litigation or current pursuit of disability
- Any condition interfering with consent, compliance, safety, or study interpretation
- Chronic use of narcotics for pain
- Claustrophobia or metal hardware interfering with MRI
- Investigators and study staff
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
G
Gisela Chelimsky, M.D.
CONTACT
M
Madison Maxwell, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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