Actively Recruiting
Pericardiotomy in Cardiac Surgery
Led by Population Health Research Institute · Updated on 2025-07-14
1400
Participants Needed
4
Research Sites
358 weeks
Total Duration
On this page
Sponsors
P
Population Health Research Institute
Lead Sponsor
M
McMaster University
Collaborating Sponsor
AI-Summary
What this Trial Is About
PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.
CONDITIONS
Official Title
Pericardiotomy in Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients greater than or equal to 18 years of age
- Requiring surgical intervention on the proximal aorta, cardiac valves, and/or coronary arteries
- Able to provide informed consent
You will not qualify if you...
- History of atrial fibrillation or flutter
- Cardiac surgery procedures not included in the inclusion criteria (planned ventricular assistance device, aortic arch, transplantation surgery)
- Prior cardiac surgery requiring opening of the pericardium
- Previous surgical instrumentation of the left pleural cavity
- Patient undergoing minimally invasive cardiac surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
2
Medical University Vienna
Vienna, State of Vienna, Austria, 1090
Actively Recruiting
3
Hamilton Health Sciences
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
4
University of Foggia, Policlinico Foggia
Foggia, Foggia, Italy, 71122
Actively Recruiting
Research Team
R
Richard Whitlock
CONTACT
P
PRINCE Coordinators
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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