Actively Recruiting
Perinatal Depression and Adverse Childhood Experiences: Prevention Trial
Led by Northwestern University · Updated on 2025-02-28
76
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
W
Women and Infants Hospital of Rhode Island
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the impact of ROSE in individuals with adverse childhood experiences. The main question it aims to answer is, compared to enhanced treatment as usual, does the delivery of ROSE within a collaborative care model improve depressive symptom trajectories and prevent the development of perinatal depression. Participants will be randomized to either enhanced treatment as usual or the ROSE intervention, delivered by a care manager within a perinatal collaborative care program. They will complete self-reported surveys of their depression symptoms every 4 weeks to inform their symptom trajectories. They will also complete clinical interviews to establish any incident diagnoses of a major depressive episode.
CONDITIONS
Official Title
Perinatal Depression and Adverse Childhood Experiences: Prevention Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- At least one prenatal visit at Northwestern Medicine
- Less than 24 weeks gestation
- Non-anomalous pregnancy
- English- or Spanish-speaking
- ACE score of 2 or higher
- Singleton pregnancy
You will not qualify if you...
- Plan to deliver outside of Prentice Women's Hospital
- Active major depressive episode
- Active substance use disorder
- Currently participating in a study with a competing intervention or outcome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northwestern Medicine
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
E
Emily S Miller, MD, MPH
CONTACT
S
Sheehan Fisher, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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