Actively Recruiting
Perinatal Transmission of MDR Bacteria
Led by Ann & Robert H Lurie Children's Hospital of Chicago · Updated on 2025-01-13
200
Participants Needed
1
Research Sites
336 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators aim to conduct a prospective surveillance study of mothers and their infants born vaginally or by scheduled C-section and who are admitted to Northwestern Medicine Prentice Women's Hospital to determine the prevalence of ESBL-E carriage in healthy post-partum women and the transmission rate of these strains to their infants. Using whole genome sequencing and a comparative genomics approach the investigators will determine the relatedness of strains among mother-infant dyads as well as identify genetic regions common to transmitted strains. It is hypothesize that; 1) given the diverse population of Chicago there will be a significant rate of gut colonization with ESBL-E among mothers admitted to Prentice, 2) ESBL-E strains isolated from neonates will be identical to those from their mothers and 3) genetic determinants of transmission are conserved across ESBL E. coli strains that are perinatally transmitted. These hypotheses will be tested using the following Aims: Aim 1: Determine the prevalence of ESBL-E gut colonization and rate of perinatal transmission among mother-infant dyads Aim 2: Identify genetic determinants of transmission common to ESBL E. coli that are perinatally transmitted. The long-term goal is to understand the unique features of persistent gut and vaginal ESBL-E colonizers and identify genetic and molecular elements that could be attractive therapeutic targets to decrease the burden of ESBL-E colonization and perinatal transmission.
CONDITIONS
Official Title
Perinatal Transmission of MDR Bacteria
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women admitted to Northwestern Medicine Women's Hospital who delivered an infant vaginally or by scheduled C-section without labor
- Infants born vaginally who are healthy and do not require transfer to the NICU
You will not qualify if you...
- Fever higher than 38 Celsius during labor
- Caesarean section performed after labor began
- Rupture of membranes or emergency delivery
- Antibiotic use during the last trimester of pregnancy, including for Group B Streptococcus
- Delivery before 35 weeks gestation
- Being immunocompromised, including HIV positive status
- Infant requiring transfer to the NICU for any reason
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Prentice Women's Hospital
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
M
Mehreen Arshad
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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