Actively Recruiting
Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
Led by National and Kapodistrian University of Athens · Updated on 2025-12-02
60
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated. To enhance the potential therapeutic effect, we will proceed to a 4-point injection technique, targeting 4 genicular nerves (superomedial, superolateral, inferomedial, recurrent peroneal genicular nerve) in a randomized controlled trial with two arms.
CONDITIONS
Official Title
Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of both sexes
- Age greater than 38 years
- Body Mass Index (BMI) up to 42 kg/m2
- Diagnosis of knee osteoarthritis by American College of Rheumatology clinical criteria
- Chronic knee pain with Numerical Rating Scale (NRS) above 5 for at least 3 months
- Grade 2 or 3 osteoarthritis by Kellgren-Lawrence classification
- Pain, creaking, and stiffness in the knee lasting at least 3 months prior to study
You will not qualify if you...
- Skin infection or periarticular/intraarticular knee infection in last 3 months
- Poorly controlled diabetes or connective tissue disease affecting the knee
- Previous total knee arthroplasty or other knee surgery
- Knee injections with corticosteroids, local anesthetic, hyaluronic acid, platelet-rich plasma, radiofrequency, or prolotherapy in last 3 months
- Knee injury or fracture in last 3 months
- Acute lumbosacral radiculopathy, peripheral neuropathy, neurological or psychiatric disease
- Pain limited to the back of the knee only
- History of limb malignancy
- History of bleeding disorder
- Pregnancy
- Allergy to local anesthetics or needle phobia
- Severe hearing loss, dementia, or language difficulties affecting communication
- Lack of reliable transportation for treatments and follow-ups
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University General Hospital of Athens "Attikon" - National and Kapodistrian University of Athens Medical School
Athens, Attica, Greece, 124 62
Actively Recruiting
Research Team
K
Konstantinos Kalimeris MD, PhD, Associate Professor of Anesthesiology, Associate Professor
CONTACT
V
Vasileios Boviatsis MD, Msc, PhD candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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