Actively Recruiting
Periodontal Health and Sodium Bicarbonate Toothpaste
Led by University of Plymouth · Updated on 2025-12-22
100
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
Sponsors
U
University of Plymouth
Lead Sponsor
H
HALEON
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment. The main question it aims to answer is: Does daily use of toothpaste affect the following outcomes: clinical oral health (plaque scores, gingival bleeding scores and periodontal pocket depths), salivary biochemical markers and the oral microbiome. Outcomes measures will be recorded at 0,3, and 6 months, during which time participants will receive either the treatment or placebo toothpaste and undergo oral hygiene instruction and PMPR over 6 months.
CONDITIONS
Official Title
Periodontal Health and Sodium Bicarbonate Toothpaste
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult participants >18 years of any gender will be recruited.
You will not qualify if you...
- Full dentures
- Diabetics
- Cancer diagnosis
- Pregnancy
- Use of antibiotics (<3 months prior to participation)
- Use of antibacterial mouthwash
- Inorganic nitrates taken less than 4 weeks before the study
- Immunosuppressants taken less than 4 weeks before the study
- BPE score of less than 3 and/or more than two 4's
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Derriford Dental Education Facility
Plymouth, United Kingdom, PL4 8AA
Actively Recruiting
Research Team
Z
Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD
CONTACT
A
Amazon Doble, BSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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