Actively Recruiting
Periodontitis and Inflammation
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-01-21
219
Participants Needed
2
Research Sites
300 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Today, to understand pathogenic mechanisms involved in periodontitis and peri-implantitis remains a challenge to identify biomarkers or therapeutic targets to improve prevention and screening, as well as the effectiveness of periodontitis and peri-implantitis treatments. The aim is to characterize, in vivo, specific molecular markers reflecting the activity of the pathology, which could lead to * improve the knowledge of the pathogenesis of periodontitis and peri-implantitis; * determine target molecules involved in tissue destruction; * determine molecular profiles of patients at local and systemic risk; * determine therapeutic targets For this purpose, biological samples will be collected (plaque, saliva, crevicular fluid) from patients with periodontitis or peri-implantitis stage 3 or 4 versus patients with a healthy periodontium. Biological samples will be collected before and all along the periodontal or peri-implantal treatment. Gingiva explants collection will be sampling within the surgical procedures (if they are needed). The primary objective is to investigate tissue and cellular expression of molecular markers associated with periodontal destruction during periodontitis or peri-implantitis in relation to periodontal infection and systemic changes in host response. A characterization of the cytokines in gingival fluid and unstimulated saliva (Luminex® technique) of patients with periodontitis or peri-implantitis versus without periodontitis or peri-implantitis will be done. The secondary objective is to study the influence of periodontitis on systemic pathologies via serum analysis of molecules and bacteria involved in periodontal destruction. Immunofluorescence evaluation of protein expression and distribution (inflammatory mediators, inflammatory pathway signaling proteins) in gingival explants, characterization of proteases (MMP) present in gingival fluid and unstimulated saliva (Luminex® technique) and microbiological analysis of the subgingival biofilm (by quantitative PCR).
CONDITIONS
Official Title
Periodontitis and Inflammation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is 18 years or older
- Patient is enrolled in a social security system or equivalent
- Patient speaks and understands French well enough to read study information
- Patient agrees to participate in the study
- For periodontitis cases: diagnosed with localized or generalized periodontitis stage 3 or 4 based on clinical exam
- For peri-implantitis cases: has at least one implant affected by peri-implantitis confirmed by clinical and radiographic exams
- For controls: has healthy gums with no history of periodontitis or peri-implantitis and requires dental surgery such as tooth extraction or pre-prosthetic surgery
You will not qualify if you...
- Received antibiotics, antibiotic prophylaxis, or anti-inflammatory treatment within 3 months before inclusion
- Pregnant or breastfeeding women
- Currently participating in another interventional research study or within exclusion period
- Under legal guardianship, curatorship, or legal protection
- Declined to participate in the research
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Service d'odontologie, hôpital Charles Foix
Ivry-sur-Seine, France, 94200
Actively Recruiting
2
Dentistry department- Rothschild hospital
Paris, France, 75012
Actively Recruiting
Research Team
M
Marjolaine GOSSET, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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