Actively Recruiting
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
Led by Peking University First Hospital · Updated on 2025-07-31
4532
Participants Needed
39
Research Sites
263 weeks
Total Duration
On this page
Sponsors
P
Peking University First Hospital
Lead Sponsor
P
Peking University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal. Dexmedetomidine is a highly selective alpha 2 adrenergic receptor agonist with sedative, analgesic, and anxiolytic effects. Studies showed that perioperative use of dexmedetomidine reduces delirium and some non-delirium complications after surgery. In long-term follow-up studies of older patients who, for other reasons, were randomized to receive either dexmedetomidine or placebo during intra- or postoperative period, dexmedetomidine use was associated with improved long-term survival. This multicenter randomized trial aims to investigate the effect of perioperative dexmedetomidine on long-term outcomes in older patients undergoing cancer surgery.
CONDITIONS
Official Title
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 60 years or older.
- Scheduled for radical cancer surgery under general anesthesia with expected duration of 2 hours or longer.
- Requires patient-controlled intravenous analgesia after surgery.
You will not qualify if you...
- Unable to communicate before surgery due to vision, hearing, speech, or other reasons.
- Undergoing surgery for breast cancer or intracranial tumor.
- Severe sinus bradycardia (less than 50 beats per minute), sick sinus syndrome, or second-degree or higher atrioventricular block without a pacemaker.
- Severe liver dysfunction classified as Child-Pugh class C.
- Severe kidney dysfunction requiring renal replacement therapy before surgery.
- Currently enrolled in other clinical studies.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 39 locations
1
The First Affiliated Hospital of China University of Science and Technology
Hefei, Anhui, China, 065001
Actively Recruiting
2
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Hefei, Anhui, China, 230001
Actively Recruiting
3
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
4
Tsinghua University Yuquan Hospital
Beijing, Beijing Municipality, China, 100040
Actively Recruiting
5
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 200032
Actively Recruiting
6
The First Affiliated Hospital of Army Medical University (Southwest Hospital)
Chongqing, Chongqing Municipality, China, 400038
Actively Recruiting
7
Fujian Provincial Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
8
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350004
Actively Recruiting
9
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, Fujian
Not Yet Recruiting
10
Jinjiang City Hospital (Shanghai Sixth People's Hospital, Fujian Hospital)
Jinjiang, Fujian, China, 362261
Actively Recruiting
11
Guangdong General Hospital
Guangzhou, Guangdong, China, 510080
Actively Recruiting
12
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China, 518034
Actively Recruiting
13
The First Affiliated Hospital of Shenzhen University
Shenzhen, Guangdong, China, 518035
Actively Recruiting
14
The Second Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China, 530005
Actively Recruiting
15
Affiliated Cancer Hospital of Guangxi Medical University
Nanning, Guangxi, China, 530021
Actively Recruiting
16
Zhejiang Cancer Hospital
Zhejiang, Hangzhou, China, 310022
Not Yet Recruiting
17
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050011
Actively Recruiting
18
Tangshan Workers' Hospital
Tangshan, Hebei, China, 063000
Not Yet Recruiting
19
The Second Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150001
Actively Recruiting
20
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150081
Actively Recruiting
21
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
22
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 463599
Actively Recruiting
23
Xiangya Hospital Central South university
Changsha, Hunan, China, 410119
Actively Recruiting
24
The First Affiliated Hospital of University of South China
Hengyang, Hunan, China, 421005
Not Yet Recruiting
25
Nanjing General Hospital of Nanjing Military Region
Nanjing, Jiangsu, China, 210000
Actively Recruiting
26
Affiliated Drum Tower Hospital, Medical School of Nanjing University
Nanjing, Jiangsu, China, 210008
Actively Recruiting
27
The Second Affiliated Hospital of Suzhou University
Suzhou, Jiangsu, China, 215004
Actively Recruiting
28
Bethune First Hospital Of Jilin University
Changchun, Jilin, China, 130031
Actively Recruiting
29
General hospital of eastern theater command
Nanjing, Nanjing, China, 210002
Not Yet Recruiting
30
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China, 750003
Not Yet Recruiting
31
People's Hospital of Ningxia Hui Autonomous Region
Yinchuan, Ningxia, China, 750011
Actively Recruiting
32
Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032
Actively Recruiting
33
Shandong Provincial Hospital Heze Hospital
Heze, Shandong, China, 274000
Actively Recruiting
34
Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine
Shanghai, Shanghai Municipality, China, 200123
Actively Recruiting
35
Shanxi Cancer Hospital
Taiyuan, Shanxi, China, 030000
Actively Recruiting
36
Shanxi Provincial People's Hospital
Taiyuan, Shanxi, China, 030012
Actively Recruiting
37
Shanxi Bethune Hospital
Taiyuan, Shanxi, China, 030032
Actively Recruiting
38
First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China, 830011
Actively Recruiting
39
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD,PhD
CONTACT
J
Jia-Hui Ma, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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