Actively Recruiting

Age: 18Years +
All Genders
ID05931068

Pre- and Postoperative Energy Expenditure in Major Liver Resection: What do we Ask From a Patient?

Led by Academisch Ziekenhuis Maastricht · Updated on 2024-08-05

20

Participants Needed

1

Research Sites

20 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying patients undergoing major elective liver surgery to better understand how their energy use changes before and after the operation. This study focuses on how the body's energy needs during recovery relate to a patient's aerobic fitness before surgery. It aims to improve personalized exercise programs that might help unfit patients recover better and reduce complications after surgery. The study observes patients without changing their treatment. It measures energy use with advanced methods like doubly labelled water and indirect calorimetry one week before and after surgery, and during hospital stays. Aerobic fitness is tested with exercise tests before surgery and at discharge. Physical activity is tracked using small wearable devices. Questionnaires about anxiety and depression are also used to understand their impact on activity and recovery. Participants will be involved in tests and measurements before and after surgery, including urine collection, exercise testing, and wearing activity monitors. Researchers assess changes in energy use, fitness, physical activity, and postoperative complications. The study lasts about 18 months and includes detailed monitoring to gather data that may help improve care for future patients undergoing major liver surgery.

CONDITIONS

Brief Title

Perioperative Energy Expenditure in Major Liver Resection

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Scheduled for open liver resection involving 3 or more segments at the MUMC+
  • Able to understand Dutch well enough to give consent and follow study instructions
Not Eligible

You will not qualify if you...

  • Cirrhotic liver
  • Unable or unwilling to perform cardiopulmonary exercise testing or indirect calorimetry
  • Liver ablation as the primary treatment
  • Surgery stopped early due to extensive cancer (open-close surgery)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - 1 week before surgery

Participants undergo preoperative assessments including energy expenditure measurements using the doubly labelled water technique and indirect calorimetry, aerobic capacity testing via cardiopulmonary exercise testing (CPET), physical activity monitoring with accelerometry, and completion of the hospital anxiety and depression scale questionnaire.

1 to 2 visits including 1 baseline visit and 1 hospital admission visit

Surgery and Immediate Post-operative Care

Duration - Approximately 10 days (hospital stay)

Participants undergo major liver resection surgery followed by hospital admission where resting energy expenditure is measured daily using indirect calorimetry on postoperative days 1, 2, and 3. Aerobic capacity testing with CPET and accelerometry monitoring continue during this period.

Daily visits in hospital for assessments until discharge

Post-operative Follow-up

Duration - Up to 1 week after surgery

Participants continue to have energy expenditure measured by the doubly labelled water technique and indirect calorimetry until one week after surgery or hospital discharge. Aerobic capacity is assessed again with CPET at hospital discharge. Physical activity monitoring with accelerometry continues until the final aerobic capacity test.

Multiple visits including hospital discharge visit

Trial Site Locations

Total: 1 location

1

Maastricht University Medical Center+

Maastricht, Netherlands

Actively Recruiting

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Research Team

N

Nicole Hildebrand, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: a systematic review.

J Moran, F Wilson, E Guinan...

https://pubmed.ncbi.nlm.nih.gov/26787788

Prehabilitation before major intra-abdominal cancer surgery: A systematic review of randomised controlled trials.

Gwendolyn Thomas, Muhammad R Tahir, Bart C Bongers...

https://pubmed.ncbi.nlm.nih.gov/31188152

On "Prehabilitation: The emperor's new clothes or a new arena for physical therapists?" Lundberg M, Archer KR, Larsson C, Rydwik E. Phys Ther. 2018;12:127-130.

Bart C Bongers, Ilona M Punt, Nico L van Meeteren

https://pubmed.ncbi.nlm.nih.gov/31108508