Actively Recruiting
Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery
Led by First Affiliated Hospital of Kunming Medical University · Updated on 2024-11-26
150
Participants Needed
1
Research Sites
593 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Perioperative neurocognitive dysfunction(PND) are common complications of major surgery among patients, could be a long-term disease, which sometimes lasts for several years, and it is meaningful to find a biomarker of PND at the early stage.As far as we know, the relationship between IL-33 and PND is not clear yet in the gastrointestinal and hepatic area. Thus, the investigators designed this study to find out the association between IL-33 and occurrence of PND, and determine whether IL-33 could be a biomarker of the early stage of PND.Study population included 150 subjects. Neuropsychological questionnaire were administrated one day before surgery and three days after surgery. And the end of the operation peripheral venous blood was sampled to measure IL-33 inflammatory protein expression in peripheral blood monocytes. Analyze the data and draw conclusions.
CONDITIONS
Official Title
Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with American Society of Anesthesiologists status I to III
- Patients requiring gastrointestinal or hepatic surgery
You will not qualify if you...
- History of mental diseases
- Current neurological disease
- Unable or unwilling to complete neurocognitive evaluation
- Preoperative Mini-Mental State Examination score below required threshold (illiteracy <17; primary school <20; middle school and higher <24)
AI-Screening
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Trial Site Locations
Total: 1 location
1
The first affiliated hospital of KUNMING medical university
Kunming, Yunnan, China, 650032
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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