Actively Recruiting
Perioperative Intravenous Nimodipine Trial
Led by University of Ioannina · Updated on 2025-07-02
40
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.
CONDITIONS
Official Title
Perioperative Intravenous Nimodipine Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled for open surgical treatment of bowel cancer at the General Hospital of Patra
You will not qualify if you...
- Age less than 18 years or greater than 75 years
- American Society of Anesthesiologists (ASA) physical status greater than III
- Allergy to nimodipine
- Unable to provide informed consent
- Known severe renal insufficiency
- Known severe bradyarrhythmia
- Daily opioid use in the 7 days before surgery
- Pain intensity greater than 5 on the Numerical Rating Scale on more than half the days in the past month
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
St. Andrews General Hospital of Patras, GREECE
Pátrai, Achaea, Greece, 263 32
Actively Recruiting
Research Team
M
Maria-Theodora Filou, MD
CONTACT
O
Ourania Patroni, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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