Actively Recruiting
Perioperative Oral Decontamination and ImmunoNuTrition (POINT) in Elderly
Led by Peking Union Medical College Hospital · Updated on 2025-01-28
592
Participants Needed
2
Research Sites
105 weeks
Total Duration
On this page
Sponsors
P
Peking Union Medical College Hospital
Lead Sponsor
F
Fujian Provincial Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this multicenter randomized controlled trial is to explore the efficacy of perioperative oral decontamination and immunonutrition supplement to prevent postoperative pulmonary complications in elderly patients(≥65 years) receiving elective non-cardiac operations. Participants will be either given immunonutrition supplement versus routine nutrition advice, and oral chlorhexidine decontamination versus routine oral care randomly. The two interventions will be compared with control groups separately regarding postoperative pulmonary complications and other outcomes.
CONDITIONS
Official Title
Perioperative Oral Decontamination and ImmunoNuTrition (POINT) in Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Undergoing major non-cardiac surgery
- Scheduled for general anesthesia and endotracheal intubation
- American Society of Anesthesiologists (ASA) physical status classification I-IV
- Intermediate to high risk of respiratory complications assessed by ARISCAT score
- Provided informed consent
You will not qualify if you...
- Emergency surgery
- Preoperative pneumonia
- Allergy to chlorhexidine
- Severe liver or kidney dysfunction
- Unable to feed orally
- Autoimmune diseases
- Taking immunosuppressant or immunoregulation medications
- Other contraindications to immunonutrition supplementation
- Expected immunonutrition intervention less than 3 days
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Actively Recruiting
2
Peking Union Medical College Hospital
Beijing, China
Actively Recruiting
Research Team
L
Lu Che, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
4
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