Actively Recruiting
The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
Led by King Abdullah International Medical Research Center · Updated on 2025-07-28
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate how giving low-dose epinephrine together with tranexamic acid affects blood loss during and after knee joint replacement surgery. It also studies how these drugs influence blood clot complications and the length of hospital stay. The study is a phase 4 clinical trial involving patients undergoing knee arthroplasty, designed to test if the combination therapy improves outcomes compared to tranexamic acid alone. Participants will be randomly assigned to one of two groups. One group receives both low-dose intravenous epinephrine and tranexamic acid, while the other group receives only tranexamic acid. The randomization is computer-generated to ensure fairness. Researchers plan to include about 80 patients to detect meaningful differences in blood loss, with monitoring continuing through the first five days after surgery. Throughout the study, participants will be closely monitored daily for blood loss, signs of blood clots, duration of hospitalization, and any side effects or complications from the medications. These assessments help researchers understand the treatments' effects and safety. The total observation period lasts until the fifth day after surgery, allowing detailed evaluation of perioperative outcomes.
CONDITIONS
Brief Title
The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing knee joint arthroplasty
- Saudi and Non-Saudi patients
- Patients who have complete medical records
- Age between 18 and 70 years
You will not qualify if you...
- End stage renal disease
- Liver cirrhosis
- Coagulopathy
- Pre-operative hemoglobin less than 10.5
- History of cerebrovascular accident or myocardial infarction in past 12 months
- History of heart failure
- History of arrhythmia
- History of pheochromocytoma, thyrotoxicosis, and glaucoma
- Pregnancy or breastfeeding
- History of deep venous thrombosis or pulmonary embolism
- Allergy to epinephrine or tranexamic acid
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 days post-operatively
Participants receive either low-dose epinephrine combined with tranexamic acid or tranexamic acid alone during knee arthroplasty surgery.
Daily visits for up to 5 days after surgery
Duration - Up to 5 days post-operatively
Participants are monitored for perioperative blood loss, thromboembolic complications, drug side effects, hospitalization duration, and other complications following surgery.
Daily visits continuing through post-operative day 5
Trial Site Locations
Total: 1 location
1
King Abdulaziz Medical City, Ministry of National Guard - Health Affairs
Riyadh, Riyadh Region, Saudi Arabia
Actively Recruiting
Research Team
D
Dr. Turki Althunayan
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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