Study of Low-Dose Epinephrine and Tranexamic Acid Effects on Blood Loss and Recovery After Knee Replacement Surgery

What this Trial Is About

This research aims to evaluate how giving low-dose epinephrine together with tranexamic acid affects blood loss during and after knee joint replacement surgery. It also studies how these drugs influence blood clot complications and the length of hospital stay. The study is a phase 4 clinical trial involving patients undergoing knee arthroplasty, designed to test if the combination therapy improves outcomes compared to tranexamic acid alone. Participants will be randomly assigned to one of two groups. One group receives both low-dose intravenous epinephrine and tranexamic acid, while the other group receives only tranexamic acid. The randomization is computer-generated to ensure fairness. Researchers plan to include about 80 patients to detect meaningful differences in blood loss, with monitoring continuing through the first five days after surgery. Throughout the study, participants will be closely monitored daily for blood loss, signs of blood clots, duration of hospitalization, and any side effects or complications from the medications. These assessments help researchers understand the treatments effects and safety. The total observation period lasts until the fifth day after surgery, allowing detailed evaluation of perioperative outcomes.

The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery