Actively Recruiting
Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer
Led by Osijek University Hospital · Updated on 2026-02-20
68
Participants Needed
1
Research Sites
68 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective study investigates the effects of neoadjuvant therapy on endothelial function, microvascular tissue density, and tissue fibrosis in patients with colorectal cancer and their association with perioperative complications. The primary objective is to assess differences in microvascular tissue density between patients who received neoadjuvant therapy and those who did not, biomarkers, and demographic factors between patients who received neoadjuvant therapy and those who underwent surgery as initial treatment, and to compare clinical outcomes. The study will include 34 patients treated with neoadjuvant therapy and 34 patients for whom surgery is the first-line treatment. Patients will be followed until discharge from the hospital, and complications after discharge will be monitored through medical records one month after surgery.
CONDITIONS
Official Title
Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 618 years with histologically confirmed colorectal cancer
- Planned surgical treatment for colorectal cancer (laparoscopic or open surgery)
- Ability to understand the study and provide written informed consent
- Both sexes
- ASA classification II or III
- Patients who received neoadjuvant therapy or those who did not receive neoadjuvant therapy
You will not qualify if you...
- Age under 18 years
- Patients who are unconscious, disoriented, or unable to provide informed consent
- Patients unable to understand the study protocol
- Emergency surgical cases
- Patients on chronic corticosteroid therapy
AI-Screening
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Trial Site Locations
Total: 1 location
1
KBC Osijek
Osijek, Croatia, 31000
Actively Recruiting
Research Team
J
Josipa Glavas Tahtler, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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