Impact of Perioperative Sepsis on Inflammatory, Cardiac, Coagulation, and microRNA Profiles in Patients Undergoing Major Abdominal Surgery

What this Trial Is About

Researchers are investigating the effects of perioperative sepsis on inflammation, blood clotting, heart function, and microRNA patterns in adults undergoing major abdominal surgery. This observational study divides 40 patients into septic and non-septic groups based on sepsis criteria and SOFA score changes. The goal is to understand biological and molecular changes linked to sepsis during surgery and explore microRNAs as early indicators of postoperative sepsis. Participants receive standard care without changes, and the study involves collecting clinical data, heart ultrasound exams, and blood samples before surgery and within 24 hours after. Blood tests measure markers of inflammation, coagulation, organ function, and heart injury, while specific microRNAs related to immune response and sepsis are analyzed. Patients are grouped after surgery by sepsis status determined through clinical assessment and SOFA scoring. Throughout the perioperative period, researchers assess differences in biological, heart, and molecular markers between groups. This includes echocardiographic measures of heart performance and levels of various blood markers. The primary focus is on how sepsis affects microRNA profiles. The study lasts from two days before surgery until one day after, with no long-term follow-up. Data collection follows ethical standards and relies on routine clinical assessments and laboratory analyses.

Perioperative Sepsis. An Epigenetic Perspective