Actively Recruiting
Perioperative Sepsis. An Epigenetic Perspective
Led by Carol Davila University of Medicine and Pharmacy · Updated on 2026-03-02
40
Participants Needed
1
Research Sites
11 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This single-center, prospective, observational study evaluates the impact of perioperative sepsis on inflammatory response, coagulation abnormalities, cardiac dysfunction, and microRNA expression in adult patients undergoing major abdominal surgery. Forty patients are enrolled and classified into septic and non-septic groups according to international sepsis definitions based on SOFA score criteria. Clinical, biochemical, echocardiographic, and molecular parameters, including selected microRNAs, are assessed preoperatively and within the first 24 hours postoperatively. The study aims to characterize pathophysiological differences associated with perioperative sepsis and to explore the potential prognostic value of microRNAs as early biomarkers of postoperative sepsis.
CONDITIONS
Official Title
Perioperative Sepsis. An Epigenetic Perspective
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Undergoing major abdominal surgery, either elective or emergency
- Able to provide written informed consent
- Biological samples available before surgery and within 24 hours after surgery
- Hemodynamically stable before surgery
You will not qualify if you...
- Surgical reintervention within 3 months after the initial surgery
- More than one surgical procedure during the same hospital stay
- Active chronic infections such as HIV, viral hepatitis, or tuberculosis
- Autoimmune or systemic inflammatory diseases
- Use of chronic immunosuppressive therapy or long-term corticosteroids
- Severe liver failure classified as Child-Pugh class C
- End-stage kidney disease requiring dialysis
- Severe existing heart disease with New York Heart Association class III or IV heart failure
- Pregnancy
- Unable or unwilling to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Institutul Clinic Fundeni
Bucharest, Sector 2, Romania, 022328
Actively Recruiting
Research Team
S
Sebastian I Isac, Assist. Prof.
CONTACT
B
Buzatu Cristina
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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