Actively Recruiting
Perioperative Steroid Dosing on the APR in AIS
Led by Emory University · Updated on 2026-02-05
50
Participants Needed
1
Research Sites
164 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to perform a prospective, randomized controlled trial investigating the clinical usage of perioperative dexamethasone usage on APR activation, postoperative morphine usage, postoperative nausea, and hospital length of stay. There will be a control control and a Dexamethasone cohort. Participants will be randomized into one of the two cohorts. Patients in the control group will receive one 8mg dose of dexamethasone intraoperatively as per standard of care anesthesia protocols. Patients randomized to the dexamethasone cohort will be administered 8 mg of dexamethasone with 3 additional doses administered at 8-hour intervals following surgery for a total of 4 doses. All study activities will tale place at Egleston during the patient's planned inpatient stay for their posterior spinal fusion. This project has the potential to validate the utility of dexamethasone as a way to optimize postoperative care following PSF for AIS by minimizing the need for opioid medications and enhancing mobility and recovery.
CONDITIONS
Official Title
Perioperative Steroid Dosing on the APR in AIS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 10 to 18 years
- Diagnosis of adolescent idiopathic scoliosis (AIS)
- Scheduled for posterior spinal fusion surgery performed by Dr. Nicholas Fletcher at Children's Healthcare of Atlanta Egleston
You will not qualify if you...
- Patients outside the age range of 10 to 18 years
- Patients with congenital or syndromic scoliosis
- Pregnant women
- Prisoners
- Patients with systemic fungal infections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children Healthcare of Atlanta
Atlanta, Georgia, United States, 30329
Actively Recruiting
Research Team
N
Nicholas Fletcher, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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