Actively Recruiting
Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation (SPOT)
Led by Centre Hospitalier Universitaire de Nice · Updated on 2025-12-08
150
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.
CONDITIONS
Official Title
Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation (SPOT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Membership of a social security scheme or equivalent
- At least 18 years of age
- Able to express consent
- Indication for unilateral or bilateral inguinal hernia repair
- General anesthesia planned and confirmed for inguinal hernia surgery regardless of surgical technique
You will not qualify if you...
- Surgical indication for another reason or hernia repair combined with another procedure
- Smoking history exceeding 35 pack-years
- History of psychiatric illness
- ASA physical status class 3 or 4 (severe or disabling general disease)
- ASA class 2 with at least one of these conditions or treatments: insulin-dependent diabetes, high blood pressure, heart rhythm disorder, thyroid disease, progressive neurological disease, long-term benzodiazepine use
- Allergy or intolerance to starch
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHPG
Monaco, Monaco, 98000
Actively Recruiting
Research Team
B
Bertrand PRUNET, PU-PH
CONTACT
N
Nicolas RIJO
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here