Actively Recruiting
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Led by University Health Network, Toronto · Updated on 2025-04-25
300
Participants Needed
3
Research Sites
141 weeks
Total Duration
On this page
Sponsors
U
University Health Network, Toronto
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.
CONDITIONS
Official Title
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old
- Undergoing unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee
You will not qualify if you...
- Total knee arthroplasty due to infection, fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
- History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
- Unlikely to comply with follow-up (e.g., no fixed address, plans to move away)
- Language difficulties preventing valid questionnaire completion
- Planned staged bilateral total knee arthroplasty
- Treating surgeon considers patient inappropriate for trial inclusion
- Any allergy or sensitivity to milk
- Pregnant or planning pregnancy during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Sunnybrook - Holland Centre
Toronto, Ontario, Canada, M4Y 1H1
Actively Recruiting
2
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5
Actively Recruiting
3
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Actively Recruiting
Research Team
J
James Khan, MD
CONTACT
N
Nour Ayach
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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