Actively Recruiting
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
Led by St. Jude Children's Research Hospital · Updated on 2026-04-29
65
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will examine sleep disordered breathing and sleep quality in participants (ages 12-18) diagnosed with sickle cell disease of any genotype. We will utilize remote peripheral arterial tonometry (PAT) and questionnaires to evaluate difficulties with sleep. PAT assessments will occur remotely in the homes of participants. Neurocognitive, behavioral, and neuroimaging evaluations will occur on the same day as a routine clinic visit. Primary Objective: Evaluate the relationship between nocturnal oxyhemoglobin saturation (SpO2) and neurocognitive functioning (working memory and verbal comprehension) in children (ages 12-18) diagnosed with sickle cell disease controlling for age, genotype, and social vulnerability. Secondary Objective: Assess differences in white matter integrity, silent cerebral infarcts, neuroinflammation, and functional connectivity among children (ages 12-18) diagnosed with sickle cell disease with and without sleep disordered breathing after controlling for age. Assess differences in self- and caregiver-reported mood and pain severity among children (ages 12-18) diagnosed with sickle cell disease with and without sleep disordered breathing after controlling for age. Exploratory Objectives: Explore the relationship between nocturnal oxyhemoglobin saturation (SpO2) and neurocognitive functioning (attention, processing speed, verbal memory, visual memory, motor dexterity) in children (ages 12-18) diagnosed with sickle cell disease controlling for age, genotype, and social vulnerability. Assess the feasibility of an ultraportable ring oximeter (BodimetricsCircul+ Ring) in children (ages 12-18) diagnosed with sickle cell disease. Assess the concordance between the Circul+Ring with the WatchPAT in children (ages 12-18) diagnosed with sickle cell disease.
CONDITIONS
Official Title
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with sickle cell disease of any genotype
- Participant in the Sickle Cell Clinical Research and Intervention Program
- Between 12 and 18 years of age at the time of enrollment
- English is the primary language
- Access to a smartphone or tablet for use with the Circul+ Ring device
You will not qualify if you...
- History of an intellectual disability
- History of a traumatic brain injury or seizure disorder
- History of a stroke
- Undergoing potential curative treatment for sickle cell disease such as stem cell transplant or gene therapy
- Currently prescribed an intervention for a sleep disorder
- Inability or unwillingness of participant or legal guardian to give written informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
A
Andrew Heitzer, PhD
CONTACT
S
Stephanie Guthrie, RN, BSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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