Actively Recruiting
The Peripheral Blood Multi-Omics Study on Sleep Loss
Led by First Affiliated Hospital of Zhejiang University · Updated on 2025-07-31
60
Participants Needed
1
Research Sites
79 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related neurodegenerative diseases, has garnered widespread attention. Sleep disorders are a typical clinical manifestation of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease and are closely related to the progression of these diseases. However, current research has yet to fully elucidate the physiological responses to sleep loss across different ages and cognitive levels, as well as the association and molecular basis between sleep loss, aging, and neurodegenerative diseases. This study aims to comprehensively characterize the transcriptional and metabolic changes in peripheral blood under sleep loss in populations of different ages and cognitive levels using multi-omics approaches and to preliminarily explore the role of sleep loss in aging and AD.
CONDITIONS
Official Title
The Peripheral Blood Multi-Omics Study on Sleep Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent form
- Meet the inclusion criteria for each study arm
You will not qualify if you...
- Failure to provide informed consent
- Unable to follow study procedures due to language barriers or cognitive impairment
- Regular use of medications altering sleep or outcome variables (e.g., opioids, benzodiazepines, Z drugs)
- History of alcohol or substance abuse, consciousness disorders, cerebrovascular disease, head injury, epilepsy, encephalitis, or other neurological disorders
- Diagnosis of schizophrenia, severe depression, anxiety disorders, or other severe psychiatric conditions
- Presence of severe arrhythmias, recent myocardial infarction (within 6 months), severe pulmonary dysfunction, renal or hepatic insufficiency, severe anemia, severe gastrointestinal diseases, tumors, or other severe medical conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
B
Benyan Luo, Prof
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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