Actively Recruiting
Peripheral and Intrarenal B Cell Study in Antibody Mediated Transplant Rejection : Phenotypic and Transcriptional Study, Study of Reactivity
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-03-18
45
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Humoral rejection of kidney transplants is responsible for a large number of kidney graft losses in a context of increasing shortage. Although it has been established that it is largely mediated by the alloreactive B lymphocyte, anti-B therapies are only partially effective. The mechanisms behind the loss of tolerance are also poorly understood, and the triggers of rejection remain to be elucidated. During this study, patients admitted for kidney graft biopsy for suspicion of rejection will be included ; patients presenting non inflammatory biopsies will be studied as controls. B cells will be extracted and cultured. Their antibodies will be studied along with reactivity towards HLA, non HLA targets and the gut microbiome. The same study will be led for late rejections needing graft removal : B cells extraction, culture, antibodies reactivity testing. Controls will be graft removal for non inflammatory causes. In both cases hight throughput sequencing the immunoglobulin genes will be performed.
CONDITIONS
Official Title
Peripheral and Intrarenal B Cell Study in Antibody Mediated Transplant Rejection : Phenotypic and Transcriptional Study, Study of Reactivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult kidney transplant recipients admitted for biopsy or graft removal in the participating nephrology departments.
- Patient participation agreement and signed consent form
- Affiliation to a health insurance system
You will not qualify if you...
- Confounding factor of renal inflammation: acute or recurrent pyelonephritis, BK virus nephropathy
- Pregnant or breast-feeding women
- Persons under legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Nephrology department, Hôpital Pitié Salpêtière
Paris, France, 75013
Actively Recruiting
2
Nephrology department, Tenon hospital
Paris, France, 75020
Not Yet Recruiting
Research Team
Y
Yanis TAMZALI, MD, MsC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here