Study of Peripheral Magnetic Stimulation Effects on Sensory Perception and Brain Activity in People with Upper Limb Amputation

What this Trial Is About

The trial investigates the use of peripheral magnetic stimulation PMS to create different types of somatosensory sensations and analyze brain activity through encephalography EEG in healthy individuals and people with upper limb amputations. It aims to understand how PMS affects nerve signals and phantom limb sensations, which could help develop new clinical treatments for amputees. The study is sponsored by the Skolkovo Institute of Science and Technology and includes participants aged 18 to 65 years. During the study, participants undergo sensory mapping and hotspot localization to determine sensory thresholds. They then receive two PMS protocols five blocks of stimulation at varying frequencies and one block of repetitive PMS rPMS. EEG electrodes placed on the scalp record brain activity at the same time as PMS is applied. This non-invasive procedure monitors responses to magnetic pulses to assess sensory perception and phantom sensations. Participants will provide feedback on their sensations and undergo EEG recordings during the PMS sessions. Researchers will measure outcomes such as pain levels using a visual analogue scale VAS over four months, sensory threshold and mapping up to six months, and pain detection assessments up to one year. The study includes healthy volunteers and patients with phantom limb pain. Safety monitoring and follow-up extend up to one year after treatment.

Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation