What is this study trying to find out about chronic knee pain?

This study is comparing different therapies to see how they affect knee movement and pain in people with chronic knee pain. Researchers are studying the effects of standard steroid injections alone and combined with peripheral nerve stimulation therapy. The goal is to better understand treatment options for managing knee pain and motion.

Who may be eligible for this chronic knee pain clinical trial?

Adults aged 18 to 85 with chronic knee pain and a pain score of 4 or higher may be eligible. The study is open to all genders, but excludes those with cognitive issues, recent drug or alcohol abuse, skin infections, allergies to study drugs, or opioid use for other reasons. Please review eligibility criteria for more details.

Is there any cost to participate in this chronic knee pain clinical trial?

Study-related care, including the study drug or procedure and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should consider their own travel plans when joining the trial.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

ID06004882

Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain A Prospective, Randomized Pilot Study

Led by M.D. Anderson Cancer Center · Updated on 2026-03-03

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating different therapies to improve knee range of motion in patients with chronic knee pain. The study compares a standard steroid injection, peripheral nerve stimulation PNS therapy combined with a steroid injection, and PNS therapy with a placebo injection. Steroid injections, containing triamcinolone and bupivacaine, are the usual treatment, and this study aims to explore the effects of adding PNS therapy alongside or instead of steroids. Participants are assigned to one of three groups one receiving a steroid injection only, another receiving PNS therapy along with a steroid injection, and the third receiving PNS therapy plus a placebo injection. PNS therapy involves implanting a small wire near the nerve causing pain, which is connected to an external device delivering electrical pulses for 60 days to block pain signals. The steroid injection is given directly into the knee joint. During the study, knee range of motion is measured using goniometry at baseline, 30, 60, and 90 days to assess changes. Researchers also track knee pain scores, use of opioids, and any complications or adverse effects. Safety is monitored through adverse event reporting averaged over one year. Participants are evaluated at multiple visits to monitor progress and outcomes throughout the study period.

CONDITIONS

Brief Title

Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Patients diagnosed with chronic knee pain with a baseline pain score of 4 or higher
Patients aged between 18 and 85 years old
Patients who have signed informed consent
If bilateral knee pain, the more severe side will be treated and counted toward study outcomes

You will not qualify if you...

Patients with cognitive dysfunction or without capacity to consent
Patients with recent history (less than 6 months) of drug or alcohol abuse
Patients with open skin lesions or currently on antibiotics for local or systemic infection
Patients allergic to local anesthesia, steroids, or adhesives
Patients on opioids for reasons other than knee pain

Research Team

Saba Javed, MD

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