Actively Recruiting
Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients
Led by Ying Wang · Updated on 2026-04-09
216
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
Sponsors
Y
Ying Wang
Lead Sponsor
N
Nantong First People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This prospective, randomized, controlled trial aimed to evaluate whether fluid resuscitation guided by the Peripheral Perfusion Index (PPI) could reduce the incidence of Acute Skin Failure (ASF) in elderly critically ill patients. A total of 216 patients aged ≥65 years with sepsis or other types of shock requiring early aggressive fluid resuscitation were enrolled and randomly assigned in a 1:1 ratio to either the PPI-guided resuscitation group or the conventional resuscitation group. The intervention group targeted maintaining PPI ≥1.4 in addition to conventional hemodynamic goals, while the control group followed standard resuscitation protocols. The primary outcome was the incidence of ASF within 7 days of ICU admission, diagnosed according to NPUAP/EPUAP (2014) criteria. Secondary outcomes included time to ASF occurrence, lactate clearance, cumulative fluid balance, organ function, and long-term prognosis.
CONDITIONS
Official Title
Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Diagnosis of sepsis or other shock requiring early and aggressive fluid resuscitation
- APACHE II score of 15 or higher at ICU admission
- Expected ICU stay of 72 hours or more
- Written informed consent from patient or authorized representative
You will not qualify if you...
- Existing stage III or higher pressure injury or skin necrosis at enrollment
- Severe skin disease or peripheral vascular disease affecting skin or blood flow assessment
- Inability to continuously monitor finger pulse oximetry (due to finger injury, amputation, or severe swelling)
- Contraindications to fluid resuscitation such as acute heart failure with fluid overload
- Expected survival less than 24 hours due to terminal illness
- Participation in another interventional clinical trial
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nantong First People's Hospital
Nantong, Jiangsu, China, 226000
Actively Recruiting
Research Team
Y
Ying Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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