Actively Recruiting
Periprostatic Neurolysis in Prostate Cancer
Led by University of Texas Southwestern Medical Center · Updated on 2025-09-09
21
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
U
Urology Care Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to assess whether inhibiting nerve activity to the prostate delays progression of disease in men with high-risk clinical features for prostate cancer. Prostate cancer has been shown to invade nerves, a mechanism that is thought to be involved in prostate cancer spread in men with high-risk cancer. When nerve activity to the prostate is blocked in mice with prostate cancer, prostate cancer growth and spread are inhibited. In a previous study we showed that doing so in humans was safe and may have anticancer therapeutic effect. In this study we will test whether one versus two injections of nerve blocking agent is more effective at reducing nerves in the prostate and whether it will slow/stop spread of prostate cancer after treatment.
CONDITIONS
Official Title
Periprostatic Neurolysis in Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male with high-risk prostate cancer as defined by NCCN criteria
- Desires surgical treatment with radical prostatectomy
- Candidate for radical prostatectomy surgery
- Clinical stage ≤ cT3a on MRI
- No seminal vesicle invasion, lymph node involvement, or metastatic disease on PSMA PET scan
- No prior prostate cancer treatment including androgen deprivation therapy, radiation, focal therapy, or cryotherapy
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
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Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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