Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Role of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery

What this Trial Is About

This research evaluates pain management approaches in patients undergoing primary total knee replacement surgery. It compares two regional anesthesia techniques to see if one method reduces persistent postoperative pain six months after surgery. The trial is randomized and sponsored by Policlinico di Monza SpA, focusing on improving recovery and pain outcomes after knee arthropathy surgery. Participants receive either a continuous adductor canal block plus an ipack block or a continuous femoral nerve block combined with a continuous sciatic nerve block immediately after surgery. Both groups are given additional pain relief medications including paracetamol, ketorolac, dexamethasone, and morphine as needed. These interventions are aimed at assessing differences in pain control effectiveness over time. During the study, patients are monitored for persistent post surgical pain up to six months after surgery. Researchers also measure acute pain and morphine use during the first 72 hours post operation. The trial includes assessments of pain levels and medication requirements to track recovery progress. The total duration of participation extends through these follow-up periods to evaluate long-term pain outcomes and treatment impact.

Persistent Post Surgical Pain After Total Knee Arthroplasty