Actively Recruiting
Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock
Led by CMC Ambroise Paré · Updated on 2026-04-02
406
Participants Needed
11
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cardiogenic shock is a life-threatening condition characterized by inadequate cardiac output, leading to organ hypoperfusion and high mortality. Maintaining mean arterial pressure (MAP) is crucial, but standard targets may be insufficient due to venous congestion. Central venous pressure (CVP) can help assess effective perfusion pressure. This study investigates whether a personalized MAP target adjusted by CVP improves organ function and survival compared to standard MAP management.
CONDITIONS
Official Title
Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Diagnosed with cardiogenic shock according to consensus definitions
- Cardiogenic shock classified as SCAI stage C or higher
- Provided consent from patient, close relative, or emergency procedure
- Covered by a social security scheme
You will not qualify if you...
- Receiving catecholamine infusion for more than 24 consecutive hours
- Central venous pressure below 5 mmHg at inclusion
- Mean arterial pressure above 70 mmHg at inclusion
- Chronic kidney disease stage G4 or G5 at inclusion
- On chronic dialysis or meeting criteria for renal replacement therapy at inclusion
- Experienced recovered cardiopulmonary arrest within 7 days before inclusion
- Already on mechanical circulatory support at inclusion
- Primary diagnosis of tamponade, pulmonary embolism, or septic shock
- Allergy to norepinephrine tartrate or related substances
- No central venous access
- Known pregnancy or currently breastfeeding
- Under legal guardianship, curatorship, or judicial protection
AI-Screening
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Trial Site Locations
Total: 11 locations
1
CHU d'Amiens-Picardie
Amiens, France, 80000
Not Yet Recruiting
2
Hôpital Henri Mondor
Créteil, France, 94010
Not Yet Recruiting
3
Hôpital Privé Jacques Cartier
Massy, France, 91300
Not Yet Recruiting
4
CMC Ambroise Paré - Hartmann
Neuilly-sur-Seine, France, 92200
Actively Recruiting
5
CHU d'Orléans
Orléans, France, 45100
Not Yet Recruiting
6
Hôpital Lariboisière
Paris, France, 75010
Not Yet Recruiting
7
Hôpital Cochin
Paris, France, 75014
Not Yet Recruiting
8
Clinique NCT + /Saint-Gatien
Saint-Cyr-sur-Loire, France, 37540
Not Yet Recruiting
9
Centre Cardiologique du Nord
Saint-Denis, France, 93200
Not Yet Recruiting
10
CHRU de Strasbourg
Strasbourg, France, 67000
Not Yet Recruiting
11
CHU de Toulouse
Toulouse, France, 31000
Not Yet Recruiting
Research Team
A
Armand MEKONTSO DESSAP, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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