Actively Recruiting
Personalization of External Beam Radiation Therapy in Localised Tumours
Led by European Institute of Oncology · Updated on 2025-07-02
35
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT). Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.
CONDITIONS
Official Title
Personalization of External Beam Radiation Therapy in Localised Tumours
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged over 18 years
- Unifocal infiltrating ductal breast carcinoma, non-special histotype
- Clinical stage T1-T2, N0
- No contraindications to MRI or metal joint prostheses from knee to shoulder or femoral stent
- Good general condition (ECOG 0-2)
- Expected active treatment such as crioablation, surgery, or radiotherapy
You will not qualify if you...
- Nodule involvement and metastasis (cN1 and/or cM1) for prostate patients
- Concomitant inflammation of the intestine
- Significant systemic diseases or ongoing oral anticoagulant therapy
- Non-compliance with dose constraints in the treatment plan
- Previous invasive cancer unless disease-free for at least 3 years
- Mental disorders preventing valid informed consent
- Histology other than non-special histotype and non-epithelial tumors for breast patients
- Male sex for breast patients
- High-risk mutation carrier patients
- Bilateral breast cancer
- Synchronous distant metastases
- Neoadjuvant therapy
- Autoimmune connective tissue diseases
- Previous radiotherapy to the chest
AI-Screening
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Trial Site Locations
Total: 1 location
1
European Institute of Oncology
Milan, Italy, Italy, 20141
Actively Recruiting
Research Team
G
Giulia Marvaso, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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