Actively Recruiting
Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma
Led by Swedish Medical Center · Updated on 2025-05-16
10
Participants Needed
1
Research Sites
188 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Proposed treatment of subjects with newly diagnosed glioblastoma with novel personalized drug regimens identified to be effective in vitro using cancer stem cells derived from their individual tumors, alongside standard of care radiation and TMZ.
CONDITIONS
Official Title
Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological diagnosis of glioblastoma (GBM, WHO grade 4)
- Age 18 years or older
- Life expectancy greater than 6 months
- Tumor accessible for surgery with intent for gross or near total resection
- Karnofsky Performance Status (KPS) of 70 or higher
- No prior systemic anti-cancer treatment
- Negative for HIV, Hepatitis B, and Hepatitis C
- Hemoglobin greater than 8 g/dL
- Absolute neutrophil count greater than 1,000/mm3
- Platelet count greater than 100,000/mm3
- Creatinine less than 2 mg/dL
- Liver enzymes (ALP, AST, ALT) less than 3 times the upper limit of normal
You will not qualify if you...
- Presence of metastatic disease
- Conditions that obscure toxicity assessment or dangerously affect drug metabolism
- Serious ongoing medical illnesses
- Poorly controlled high blood pressure
- History of heart attack or unstable angina within the past 6 months
- History of stroke or transient ischemic attack within the past 6 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Swedish Medical Center
Seattle, Washington, United States, 98122
Actively Recruiting
Research Team
C
Charles S Cobbs, M.D.
CONTACT
P
Parvinder Hothi, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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