Actively Recruiting
Personalized DBS Targeting for Treating Depression
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-04-27
5
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to optimize the target brain areas for deep brain stimulation (DBS) for depression based on personalized brain imaging and stereo-electroencephalography（SEEG), to administer long-term DBS treatment in the target brain areas, to assess the effectiveness and safety of DBS for refractory depression and to validate the method of personalized optimization of DBS targets. The main questions it aims to answer are: 1. Where is the optimal DBS target brain region for each patient? 2. What are the optimal DBS parameters for each patient ? 3. What are the neural biomarkers of depression symptoms for each patient? 4. Are the optimized DBS strategies effective in treating refractory depression?
CONDITIONS
Official Title
Personalized DBS Targeting for Treating Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A psychiatrist-confirmed diagnosis of major depressive disorder according to DSM-V
- Diagnosed by two trained psychiatrists with consistent diagnosis
- History of depression lasting at least 12 months with failure to respond to two or more antidepressants
- 17-item Hamilton Rating Scale for Depression (HAMD) score of 20 or higher at screening
- Gross Assessment of Functioning (GAF) score of 50 or less
- Ability to understand the therapy and provide informed consent by patient or legal guardian
You will not qualify if you...
- Severe or unstable cardiac, hepatic, renal, endocrine, hematologic, or other medical disorders
- Co-morbid psychiatric disorders other than depression (except generalized anxiety)
- History of substance abuse within 12 months
- History of epilepsy or febrile convulsions in childhood
- Suicide attempts within past 6 months or more than two attempts within past 2 years
- Women who are breastfeeding, pregnant, or planning pregnancy during the study
- Contraindications to DBS surgery or MRI
- Education level of 9 years or less
- Patients who are involuntarily hospitalized
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
J
Junming Zhu, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here