Actively Recruiting
Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Led by Charite University, Berlin, Germany · Updated on 2026-03-02
60
Participants Needed
2
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems. Current treatments don\'t fully prevent OA from developing. This study is testing a new 12-week exercise program designed to improve how the knee moves, using a special sensor-based system. The goal is to reduce joint inflammation and prevent the development of OA in patients who have had knee surgery.
CONDITIONS
Official Title
Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent
- Adult subjects between 18 to 50 years old at the time of screening
- Primary ACL reconstruction within a maximum of 6 months after a unilateral ACL injury
- Complete baseline assessment between 8 and 12 weeks after ACL reconstruction
You will not qualify if you...
- Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury)
- Previous surgeries on the study knee (except for the ACL reconstruction)
- Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray)
- Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity)
- Body mass index 6 30 kg/m2
- Inflammatory arthropathies
- Immunosuppression due to illness or medication
- Sepsis or hemostasis disorders
- Severe uncontrolled inflammatory disease or autoimmune disease (e.g., ulcerative colitis, Crohn's disease, etc.)
- Having malignancy and undergoing treatment including chemotherapy, radiotherapy, or immunotherapy
- Contraindications for MRI, including pacemakers, defibrillators, metal implants, pregnancy, sensorineural hearing loss above 30 dB, tinnitus and claustrophobia
- Unable to freely give their informed consent (e.g., individuals under legal guardianship)
- Currently enrolled in or has not yet completed a period of at least 5 times as the half-life time of the drug used in the previous trial since ending other investigational device or drug trial(s)
- Patients who are dependent on the sponsor, investigator, or study site
- Pregnant or breast-feeding women or women of childbearing potential not protected by an effective contraceptive method of birth control (defined as pearl index < 1)
- Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the Investigator, may invalidate communication with the Investigator and/or designated study personnel
- Patients who are committed to an institution by virtue of an order issued by either the judicial or the administrative authorities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Charité - Universitätsmedizin Berlin, BeMoveD - Berlin Movement Diagnostics
Berlin, Germany, 10117
Actively Recruiting
2
Charité - Universitätsmedizin Berlin
Berlin, Germany, 10117
Actively Recruiting
Research Team
W
Winkler, Prof. Dr.med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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