Actively Recruiting
Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2025-12-08
538
Participants Needed
10
Research Sites
272 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rationale Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. The identification of ARDS phenotypes, based on focal or non-focal lung morphology, can be helpful to better target mechanical ventilation strategies of individual patients. Lung ultrasound (LUS) is a non-invasive tool that can accurately distinguish 'focal' from 'non-focal' lung morphology. The investigators hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients will lead to a reduction in 90-day mortality compared to conventional mechanical ventilation.
CONDITIONS
Official Title
Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admitted to a participating ICU
- Receiving invasive mechanical ventilation
- Meet Berlin criteria for moderate or severe ARDS
You will not qualify if you...
- Under 18 years of age
- Participating in other interventional studies with conflicting endpoints
- Conditions making lung ultrasound not feasible (e.g., subcutaneous emphysema, morbid obesity, wounds)
- Mechanical ventilation for more than 7 consecutive days in the past 30 days
- History of ARDS in the previous month
- Body mass index over 40 kg/m²
- Intracranial hypertension
- Broncho-pleural fistula
- Chronic respiratory diseases needing long-term oxygen or respiratory support
- Pulmonary fibrosis with vital capacity less than 50%
- Previously randomized in the PEGASUS study
- Receiving extracorporeal membrane oxygenation (ECMO)
- Moribund or near end of life
- Lack of informed consent
AI-Screening
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Trial Site Locations
Total: 10 locations
1
Chu-Brugmann
Brussels, Belgium
Actively Recruiting
2
Bispebjerg Hospital
Copenhagen, Denmark
Actively Recruiting
3
Nordsjaellands Hospital
Hillerød, Denmark
Actively Recruiting
4
Evaggelismos Hospital
Athens, Greece
Actively Recruiting
5
Galway University Hospitals
Galway, Ireland
Actively Recruiting
6
Ospedale Generale Regionale F. Miulli
Acquaviva delle Fonti, Bari, Italy
Actively Recruiting
7
Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
Bari, Italy
Actively Recruiting
8
Amsterdam UMC, location VUmc
Amsterdam, North Holland, Netherlands, 1081HV
Actively Recruiting
9
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105 AZ
Actively Recruiting
10
Centralny Szpital Kliniczny MSWiA
Warsaw, Poland
Actively Recruiting
Research Team
J
Jante S Sinnige, M.D.
CONTACT
M
Marry R Smit, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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