Actively Recruiting
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
Led by Senthil Sadhasivam · Updated on 2026-04-14
700
Participants Needed
4
Research Sites
255 weeks
Total Duration
On this page
Sponsors
S
Senthil Sadhasivam
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants
CONDITIONS
Official Title
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult women over 18 years old of all races
- American Society of Anesthesiologists Classification (ASA) physical status 1 to 3
- Undergoing elective Cesarean section
- Willing to receive in-patient opioids
You will not qualify if you...
- Uncontrolled diabetes (gestational or pre-existing) or hypertension (including pre-eclampsia, eclampsia, or chronic)
- History of opioid misuse before or during pregnancy by self-report or clinical notes
- Preoperative severe pain and opioid use or misuse
- Allergy to oxycodone
- Significant neurological disorders
- Liver and renal diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Riley Children's Hospital- Clinics / Labor and Delivery Unit
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
Washington University Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
3
UPMC Magee Women's Hospital
Pittsburgh, Pennsylvania, United States, 15213
Not Yet Recruiting
4
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260
Actively Recruiting
Research Team
S
Senthilkumar Sadhasivam, MD, MPH
CONTACT
D
Dayana Alsamsam, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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