Actively Recruiting
Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache
Led by Ankara City Hospital Bilkent · Updated on 2026-01-27
90
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates a novel treatment approach for medication overuse headache (MOH) using greater occipital nerve pulsed radiofrequency (GONPRF). Three treatment strategies are compared: Standard Treatment: Limitation of overused acute headache medications, lifestyle counseling, and continuation of existing preventive medications. Primary GONPRF: GONPRF administered in addition to standard treatment. Modified GONPRF: GONPRF administered as a second-line intervention in individuals who do not respond adequately to standard treatment alone. The study assesses whether GONPRF, when applied early or after an initial period of standard care, reduces monthly headache days more rapidly and effectively than standard treatment alone. Outcomes are evaluated over a 6-month follow-up period using headache diaries and scheduled clinical assessments. This is a randomized controlled trial designed to systematically evaluate the clinical benefit of GONPRF in patients with medication overuse headache.
CONDITIONS
Official Title
Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years
- Diagnosed with Medication Overuse Headache (MOH) according to ICHD-3 criteria
- No laboratory evidence of bleeding or clotting disorders
- No active infection
- Not pregnant and no suspicion of pregnancy
- No history of craniocervical surgery affecting the intervention area
- Able to understand the study, provide consent, and follow treatment
You will not qualify if you...
- Changes in preventive treatment for migraine or tension-type headache within the last 3 months
- Severe systemic diseases such as uncontrolled diabetes, serious cardiovascular disease, or malignancy
- Psychiatric disorders including current antidepressant use or psychiatric follow-up
- History of alcohol or substance abuse
- Pregnancy, breastfeeding, or planning pregnancy within 12 months
- Use of other prophylactic headache treatments concurrently
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
Research Team
Ş
Şükriye Dadalı, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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