Actively Recruiting
Personalized Real-Time DBS and PD Mechanisms
Led by David Escobar · Updated on 2026-05-14
25
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
Sponsors
D
David Escobar
Lead Sponsor
T
The Cleveland Clinic
Collaborating Sponsor
AI-Summary
What this Trial Is About
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.
CONDITIONS
Official Title
Personalized Real-Time DBS and PD Mechanisms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent.
- Clinical diagnosis of idiopathic Parkinson's disease.
- Determined, as per standard of care, to be a candidate for deep brain stimulation (DBS) surgery targeting the subthalamic nucleus.
- Ability to tolerate delays in taking daily standard Parkinson's disease medications.
You will not qualify if you...
- Secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's disease.
- Condition that significantly increases risk of interfering with study compliance, safety, or outcome as judged by investigators.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
D
David Escobar, PhD
CONTACT
J
Jeffrey Negrey, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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