Actively Recruiting
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
Led by Samsung Medical Center · Updated on 2026-04-28
60
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
Sponsors
S
Samsung Medical Center
Lead Sponsor
N
National Research Foundation of Korea
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to conventional high-frequency rTMS therapy on bilateral primary motor cortex (M1). Investigators hypothesized that the functional reserve of each patient with Parkinson's disease will be different, and therefore an appropriate simulating target for rTMS therapy is needed. In addition, this approach could be more effective compared to conventional protocols applied to patient with Parkinson's disease regardless of their severity, predicted mechanism of motor function recovery, or functional reserves.
CONDITIONS
Official Title
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Parkinson's disease by UK Parkinson's Disease Society Brain Bank criteria
- Modified Hoehn and Yahr stage between 2 and 4
- Able to walk on flat surfaces without a gait aid
- Aged 50 years or older
- Willing to sign informed consent
You will not qualify if you...
- Contraindications to rTMS such as epilepsy, metal implants in the head, or history of craniotomy
- Cognitive impairment based on Montreal Cognitive Assessment (MoCA) below educational thresholds
- Other neurological conditions like spinal cord injury or stroke
- Major psychiatric disorders including major depression, schizophrenia, or dementia
- Severe on-off phenomena or dyskinesia making study participation unsuitable
- Contraindications to MRI
- Pregnant or lactating
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
Research Team
W
Won Hyuk Chang, PhD
CONTACT
H
Ho Seok Lee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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