Actively Recruiting
Personalized Second Chance Breast Conservation (PSCBC): A Prospective Phase II Clinical Study
Led by Weill Medical College of Cornell University · Updated on 2026-01-27
120
Participants Needed
3
Research Sites
808 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of the study is to investigate the feasibility of enabling a second chance for breast conservation in patients with in-breast recurrences after a previous lumpectomy and RT, investigators propose to test partial breast irradiation with the target volume encompassing the entire surgical bed with 1.0-1.5 cm margins. An additional goal of the study is to investigate the feasibility of enabling a second chance for breast conservation in patients with inbreast recurrences after a previous lumpectomy and PBI, the investigators propose to test whole breast RT (WBRT) with the target as the whole breast volume.
CONDITIONS
Official Title
Personalized Second Chance Breast Conservation (PSCBC): A Prospective Phase II Clinical Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Isolated ipsilateral unifocal breast lesions
- Tumor size less than 2-3 cm with no skin involvement
- Histologically confirmed invasive breast carcinoma or carcinoma in situ
- Negative surgical margins after resection
- 0 to 3 positive axillary lymph nodes without extracapsular extension
- No synchronous distant metastases
- Age 18 years or older
- At least 12 months between initial breast conserving therapy and recurrence
- Previous whole breast irradiation or partial breast radiotherapy
- Technical feasibility for study treatments
- Any systemic therapy allowed
- Signed informed consent for clinical and research purposes
You will not qualify if you...
- Regional recurrences in axillary or supraclavicular areas
- Positive surgical margins after resection
- Presence of metastatic disease
- Poor cosmetic outcome from previous surgery and radiation
- Extensive intraductal component
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
New York Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States, 10065
Actively Recruiting
2
New York Presbyterian Hospital - Queens
New York, New York, United States, 10065
Actively Recruiting
3
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
Research Team
F
Fabiana Gregucci
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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