Actively Recruiting
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-02-23
1000
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
Sponsors
A
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead Sponsor
L
Leiden University Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP). FAP patients are at high risk for developing duodenal adenomas, which can lead to duodenal cancer in a small percentage of cases. The study aims to improve prevention of advanced neoplasia by removing lesions early, addressing concerns about current classification and treatment methods that may not adequately predict or prevent cancer. This study involves one group where participants receive endoscopic surveillance and interventions according to a personalized schedule. The intervals between endoscopies range from 3-6 months up to 5 years, depending on the severity of polyposis and previous treatments. The protocol focuses on monitoring and removing lesions to prevent cancer development and avoid the need for risky surgery. Participants will undergo regular endoscopic examinations and interventions as needed, with follow-up evaluations extending up to five years. Researchers will monitor the occurrence of advanced neoplasia, recurrence rates after different endoscopic treatments, intervention feasibility, diagnostic accuracy, complication rates, surveillance burden, and any surgeries performed. These assessments aim to provide comprehensive safety and effectiveness data for the personalized protocol.
CONDITIONS
Brief Title
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of familial adenomatous polyposis (FAP) confirmed by genetic testing or clinical diagnosis
- Age 18 years or older
You will not qualify if you...
- Endoscopic removal of all polyps with an indication for removal not possible or feasible
- Presence of gastric or duodenal cancer at baseline endoscopy
- Need for surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants undergo personalized endoscopic surveillance with intervals between 3 to 6 months and up to 5 years, depending on the severity of polyposis and performed endoscopic interventions.
Visits every 3 to 6 months to 5 years depending on individual surveillance intervals
Trial Site Locations
Total: 2 locations
1
MD Anderson
Houston, Texas, United States, 77030
Actively Recruiting
2
Academic Medical Centre
Amsterdam, North Holland, Netherlands, 1105AZ
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here