Actively Recruiting
Personalized Therapies in Inflammatory Complex Disease
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-20
32
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
Inflammatory diseases may display atypical features making such patients impossible to classify. Management of these cases in daily practice cannot rely on the results of clinical trials nor on guidelines. DNA and RNA mapping have become major tools to understand and sometimes direct the treatment strategy in oncology. This study aims to test whether a precise analysis of molecular pathways in inflammatory, non classified diseases, can constitute a predictive tool of therapeutic efficiency
CONDITIONS
Official Title
Personalized Therapies in Inflammatory Complex Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Patients with inflammatory non-classified disease affecting at least 2 organs including skin
- Skin involvement is mandatory for tissue comparison
- Signed informed consent
- Disease significantly impairs quality of life
- Disease resistant to at least two prior treatments such as Hydroxychloroquine, Methotrexate, Corticosteroids, and others
You will not qualify if you...
- Disease without lesional and healthy skin areas suitable for biopsy
- Refusal to undergo biopsies
- Pregnancy or breastfeeding
- Women of child-bearing potential not able to use effective contraception methods
- Disease requiring urgent treatment
- Lack of health insurance or social security
- Participation in another interventional trial
- Under legal protection
- Unable to respect washout periods for certain medications before biopsy and treatment
- Contraindications to treatments including severe or active infections such as tuberculosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Cochin
Paris, France, 75014
Actively Recruiting
Research Team
S
Selim ARACTINGI, PhD
CONTACT
C
Christelle AUGER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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